Mixed culture biocatalytic production of the high-value biochemical 7-methylxanthine.

ABSTRACT:

Background

7-Methylxanthine, a derivative of caffeine noted for its lack of toxicity and ability to treat and even prevent myopia progression, is a high-value biochemical with limited natural availability. Attempts to produce 7-methylxanthine through purely chemical methods of synthesis are faced with complicated chemical processes and/or the requirement of a variety of hazardous chemicals, resulting in low yields and racemic mixtures of products. In recent years, we have developed engineered microbial cells to produce several methylxanthines, including 3-methylxanthine, theobromine, and paraxanthine. The purpose of this study is to establish a more efficient biosynthetic process for the production of 7-methylxanthine from caffeine.

Results

Here, we describe the use of a mix

SUBMITTER: Mock MB 

PROVIDER: S-EPMC9830774 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature