Enterovirus B types cause severe infection in infants aged 0-3 months.

ABSTRACT:

Background

Enterovirus (EV) infections are being increasingly seen in younger infants, often being more severe than in older children. The risk factors of EV infection in infants have been inadequately investigated till date.

Methods

We conducted a retrospective study on hospitalized children with laboratory-confirmed EV infection (50 infants aged 0-3 months and 65 older than 3 months) at a tertiary care center in China. Prevalence, clinical characteristics, and genetic features of the virus were analyzed, and independent predictors for severe infection were assessed.

Results

Clinical findings showed that severe infection was more common in infants aged 0-3 months than in older children (78.0% vs. 35.4%, p < 0.001), with higher morbidity of pneumonia, meningitis, and

SUBMITTER: Yang X 

PROVIDER: S-EPMC9830867 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature