The bovine foot skin microbiota is associated with host genotype and the development of infectious digital dermatitis lesions.

ABSTRACT:

Background

Bovine Digital Dermatitis (BDD) is a prevalent infectious disease, causing painful foot skin lesions and lameness in cattle. We describe herein the bovine foot skin microbiota and its associations with BDD using 16S rRNA gene amplicon and shotgun metagenomic sequencing on samples from 259 dairy cows from three UK dairy farms.

Results

We show evidence of dysbiosis, and differences in taxonomy and functional profiles in the bovine foot skin microbiome of clinically healthy animals that subsequently develop BDD lesions, compared to those that do not. Our results suggest that taxonomical and functional differences together with alterations in ecological interactions between bacteria in the normal foot skin microbiome may predispose an animal to develop BDD lesions. Us

SUBMITTER: Bay V 

PROVIDER: S-EPMC9830885 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature