Durable immune responses after BNT162b2 vaccination in home-dwelling old adults.

ABSTRACT:

Objectives

Elderly are an understudied, high-risk group vulnerable to severe COVID-19. We comprehensively analyzed the durability of humoral and cellular immune responses after BNT162b2 vaccination and SARS-CoV-2 infection in elderly and younger adults.

Methods

Home-dwelling old (n = 100, median 86 years) and younger adults (n = 449, median 38 years) were vaccinated with two doses of BNT162b2 vaccine at 3-week intervals and followed for 9-months. Vaccine-induced responses were compared to home-isolated COVID-19 patients (n = 183, median 47 years). Our analysis included neutralizing antibodies, spike-specific IgG, memory B-cells, IFN-γ and IL-2 secreting T-cells and sequencing of the T-cell receptor (TCR) repertoire.

Results

Spike-specific breadth and depth of the CD4<

SUBMITTER: Hansen L 

PROVIDER: S-EPMC9830931 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature