NetSHy: network summarization via a hybrid approach leveraging topological properties.

ABSTRACT:

Motivation

Biological networks can provide a system-level understanding of underlying processes. In many contexts, networks have a high degree of modularity, i.e. they consist of subsets of nodes, often known as subnetworks or modules, which are highly interconnected and may perform separate functions. In order to perform subsequent analyses to investigate the association between the identified module and a variable of interest, a module summarization, that best explains the module's information and reduces dimensionality is often needed. Conventional approaches for obtaining network representation typically rely only on the profiles of the nodes within the network while disregarding the inherent network topological information.

Results

In this article, we propose NetSHy, a

SUBMITTER: Vu T 

PROVIDER: S-EPMC9831052 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature