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Hyalocyte origin, structure, and imaging.

ABSTRACT:

Introduction

Hyalocytes have been recognized as resident tissue macrophages of the vitreous body since the mid-19^th century. Despite this, knowledge about their origin, turnover, and dynamics is limited.

Areas covered

Historically, initial studies on the origin of hyalocytes used light and electron microscopy. Modern investigations across species including rodents and humans will be described. Novel imaging is now available to study human hyalocytes in vivo. The shared ontogeny with retinal microglia and their eventual interdependence as well as differences will be discussed.

Expert opinion

Owing to a common origin as myeloid cells, hyalocytes and retinal microglia have similarities, but hyalocytes appear to be distinct as resident macrophages of the vitreous body.

SUBMITTER: Wieghofer P

PROVIDER: S-EPMC9831111 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Hyalocyte origin, structure, and imaging.

Wieghofer Peter P Engelbert Michael M Chui Toco Yp TY Rosen Richard B RB Sakamoto Taiji T Sebag J J

Expert review of ophthalmology 20220906 4

<h4>Introduction</h4>Hyalocytes have been recognized as resident tissue macrophages of the vitreous body since the mid-19<sup>th</sup> century. Despite this, knowledge about their origin, turnover, and dynamics is limited.<h4>Areas covered</h4>Historically, initial studies on the origin of hyalocytes used light and electron microscopy. Modern investigations across species including rodents and humans will be described. Novel imaging is now available to study human hyalocytes <i>in vivo.</i> The ...[more]

PMID: 36632192

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