Pathogen-specific T Cells: Targeting Old Enemies and New Invaders in Transplantation and Beyond.

ABSTRACT: Adoptive immunotherapy with virus-specific cytotoxic T cells (VSTs) has evolved over the last three decades as a strategy to rapidly restore virus-specific immunity to prevent or treat viral diseases after solid organ or allogeneic hematopoietic cell-transplantation (allo-HCT). Since the early proof-of-principle studies demonstrating that seropositive donor-derived T cells, specific for the commonest pathogens post transplantation, namely cytomegalovirus or Epstein-Barr virus (EBV) and generated by time- and labor-intensive protocols, could effectively control viral infections, major breakthroughs have then streamlined the manufacturing process of pathogen-specific T cells (pSTs), broadened the breadth of target recognition to even include novel emerging pathogens and enabled off-the-shelf

SUBMITTER: Papadopoulou A 

PROVIDER: S-EPMC9831191 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature