Reversion of a resistance-breaking mutation shows reversion costs and high virus diversity at necrotic local lesions.

ABSTRACT: An instance of host range evolution relevant to plant virus disease control is resistance breaking. Resistance breaking can be hindered by across-host fitness trade-offs generated by negative effects of resistance-breaking mutations on the virus fitness in susceptible hosts. Different mutations in pepper mild mottle virus (PMMoV) coat protein result in the breaking in pepper plants of the resistance determined by the L³ resistance allele. Of these, mutation M138N is widespread in PMMoV populations, despite associated fitness penalties in within-host multiplication and survival. The stability of mutation M138N was analysed by serial passaging in L³ resistant plants. Appearance on passaging of necrotic local lesions (NLL), indicating an effective L³ resistanc

SUBMITTER: Moreno-Perez MG 

PROVIDER: S-EPMC9831284 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature