Cross-variant proof predictive vaccine design based on SARS-CoV-2 spike protein using immunoinformatics approach.

ABSTRACT:

Background

Coronavirus Disease (COVID-19) is caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 virus is evolving continuously. The omicron variant of SARS-CoV-2 has the highest mutation in its spike protein, thus making the presently available vaccine ineffective or reducing its efficiency. Furthermore, the majority of the vaccines are constructed using a spike protein sequence from wild-type SARS-CoV-2. This raises the possibility of the virus evolving to the point where the vaccine's effectiveness is completely lost, even after booster doses. The study aims to develop a predictive vaccine as well as the epitopes for the updating of the vaccine sequences of currently available vaccines. In this study, following the immunoinformatics approac

SUBMITTER: Sahu LK 

PROVIDER: S-EPMC9831375 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature