Cisplatin-Loaded Tobacco Mosaic Virus for Ovarian Cancer Treatment.

ABSTRACT: Ovarian cancer is the foremost cause of gynecological cancer and a major cause of cancer death in women. Treatment for advanced stage is surgical debulking followed by chemotherapy; however, most patients relapse with more aggressive and therapy-resistant tumors. There is a need to develop drug delivery approaches to deliver platinum therapies to tumors to increase efficacy while maintaining safety. Toward this goal, we utilized the protein nanotubes from the plant virus, tobacco mosaic virus (TMV), as a drug carrier. Specifically, the nanochannel of TMV was loaded with the active dication form of cisplatin (cisPt²⁺), making use of the negatively charged Glu acid side chains that line the interior channel of TMV. We achieved a loading efficiency with ∼2700 cisPt²⁺ per

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC9831511 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature