Inducible lncRNA transgenic mice reveal continual role of HOTAIR in promoting breast cancer metastasis.

ABSTRACT: HOTAIR is a 2.2-kb long noncoding RNA (lncRNA) whose dysregulation has been linked to oncogenesis, defects in pattern formation during early development, and irregularities during the process of epithelial-to-mesenchymal transition (EMT). However, the oncogenic transformation determined by HOTAIR in vivo and its impact on chromatin dynamics are incompletely understood. Here, we generate a transgenic mouse model with doxycycline-inducible expression of human HOTAIR in the context of the MMTV-PyMT breast cancer-prone background to systematically interrogate the cellular mechanisms by which human HOTAIR lncRNA acts to promote breast cancer progression. We show that sustained high levels of HOTAIR over time increased breast metastatic capacity and invasivenes

SUBMITTER: Ma Q 

PROVIDER: S-EPMC9831604 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature