Early intestinal microbiota changes in aged and adult mice with sepsis.

ABSTRACT:

Background

The mortality rate associated with sepsis in elderly individuals is higher than that in younger individuals. The intestinal microbiota has been demonstrated to play an important role in the occurrence and development of sepsis. The purpose of this study was to investigate the differences in the intestinal microbiota between aged and adult mice with sepsis.

Methods

Thirty male C57BL mice were randomly divided into two groups: 15 in the adult group (AD group) and 15 in the age group (Age group). All the mice underwent caecal ligation and puncture to induce sepsis. Mice faeces were collected, and analysed using 16S rRNA sequencing. The liver and colon tissues were collected.

Results

There were significant differences in intestinal microbiota composition betwee

SUBMITTER: Yuan Y 

PROVIDER: S-EPMC9831679 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature