Visualization of Domain- and Concentration-Dependent Impact of Thrombomodulin on Differential Regulation of Coagulation and Fibrinolysis.

ABSTRACT:

Background

 Thrombomodulin (TM) functions as a dual modulator-anticoagulant and antifibrinolytic potential-by the thrombin-dependent activation of protein C and thrombin-activatable fibrinolysis inhibitor (TAFI). Activated TAFI cleaves the C-terminal lysine of partially degraded fibrin and inhibits both plasminogen binding and its activation on the fibrin surface. We have reported previously that activated platelets initiate fibrin network formation and trigger fibrinolysis after the accumulation of tissue-type plasminogen activator and plasminogen.

Objective

 To analyze the effects of domain-deletion variants of TM on coagulation and fibrinolysis at different concentrations.

Methods

 Domain-deletion variants of TM, such as D123 (all extracellular regions), E3456 (min

SUBMITTER: Mochizuki L 

PROVIDER: S-EPMC9831690 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature