High MCM8 expression correlates with unfavorable prognosis and induces immune cell infiltration in hepatocellular carcinoma.

ABSTRACT:

Background

MCM8 has been reported highly expressed in several human malignancies. However, its role in HCC has not yet been researched.

Methods

The prognostic significance of MCM8 mRNA expression was analyzed using datasets from TCGA and GEO databases. Immunohistochemistry (IHC) assay was used to detect the MCM8 protein expression in HCC tissues. The Cox regression analysis was employed to determine the independent prognostic value of MCM8. Then, we established a nomogram for OS and RFS prediction based on MCM8 protein expression. We analyzed the DNA methylation and genetic alteration of MCM8 in HCC. Moreover, GO, KEGG and GSEA were utilized to explore the potential biological functions of MCM8. Subsequently, we evaluate the correlations between MCM8 expression and compositi

SUBMITTER: Yu M 

PROVIDER: S-EPMC9831725 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature