Moderate-vigorous physical activity attenuates premature senescence of immune cells in sedentary adults with obesity: a pilot randomized controlled trial.

ABSTRACT: Despite the well-known senolytic effects of physical exercise on immune cells in older adults, the effect of physical activity (PA) on premature immune senescence in sedentary adults with obesity remains largely unknown. This pilot study aimed to investigate the role of objectively measured physical behaviors and Fitbit watch-based free-living PA intervention in premature senescence of immune cells in sedentary adults with obesity. Forty-five participants were recruited in the cross-sectional analysis, and forty of them further participated in the randomized controlled trial. We found that objectively measured moderate-vigorous PA was independently and inversely correlated with the expression of p16^INK4a and p21^Cip1 in the peripheral blood mononuclear cell (PBMCs) of

SUBMITTER: Chen XK 

PROVIDER: S-EPMC9831733 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature