Epigenetic aging is associated with aberrant neural oscillatory dynamics serving visuospatial processing in people with HIV.

ABSTRACT:

Background

Despite effective antiretroviral therapy, cognitive impairment and other aging-related comorbidities are more prevalent in people with HIV (PWH) than in the general population. Previous research examining DNA methylation has shown PWH exhibit accelerated biological aging. However, it is unclear how accelerated biological aging may affect neural oscillatory activity in virally suppressed PWH, and more broadly how such aberrant neural activity may impact neuropsychological performance.

Methods

In the present study, participants (n = 134) between the ages of 23 - 72 years underwent a neuropsychological assessment, a blood draw to determine biological age via DNA methylation, and a visuospatial processing task during magnetoencephalography (MEG). Our analyses focused

SUBMITTER: Schantell M 

PROVIDER: S-EPMC9831734 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature