A nomogram for predicting prognosis of multiple myeloma patients based on a ubiquitin-proteasome gene signature.

ABSTRACT:

Background

Multiple myeloma (MM) is a malignant hematopoietic disease that is usually incurable. However, the ubiquitin-proteasome system (UPS) genes have not yet been established as a prognostic predictor for MM, despite their potential applications in other cancers.

Methods

RNA sequencing data and corresponding clinical information were acquired from Multiple Myeloma Research Foundation (MMRF)-COMMPASS and served as a training set (n=787). Validation of the prediction signature were conducted by the Gene Expression Omnibus (GEO) databases (n=1040). To develop a prognostic signature for overall survival (OS), least absolute shrinkage and selection operator regressions, along with Cox regressions, were used.

Results

A six-gene signature, including KCTD12, SIAH1, TRIM5

SUBMITTER: Ji D 

PROVIDER: S-EPMC9831738 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature