Development of a 7-miRNA prognostic signature for patients with bladder cancer.

ABSTRACT:

Background

Bladder carcinoma (BC) represents one of the most prevalent malignant cancers, while predicting its clinical outcomes using traditional indicators is difficult. This study aimed to develop a miRNA signature for the prognostic prediction of patients with BC.

Materials and methods

MiRNAs that expressed differentially were identified between 413 BC and 19 non-tumor patients, whose prognostic values were evaluated using univariate and multivariate Cox regression analyses. The independent prognostic factors were screened out and were used to establish a signature. The risk score of the signature was calculated. Receiver operating characteristic (ROC) curves and Kaplan-Meier curves were used to verify the predictive performance of the miRNA signature and the risk score.

SUBMITTER: Xv Y 

PROVIDER: S-EPMC9831742 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature