Human Monoclonal IgE Antibodies-a Major Milestone in Allergy.

ABSTRACT:

Purpose of review

Bound to its high affinity receptor on mast cells and basophils, the IgE antibody molecule plays an integral role in the allergic reaction. Through interactions with the allergen, it provides the sensitivity and specificity parameters for cell activation and mediator release that produce allergic symptoms. Advancements in human hybridoma technologies allow for the generation and molecular definition of naturally occurring allergen-specific human IgE monoclonal antibodies.

Recent findings

A high-resolution structure of dust mite allergen Der p 2 in complex with Fab of the human IgE mAb 2F10 was recently determined using X-ray crystallography. The structure reveals the fine molecular details of IgE 2F10 binding its 750 Ų conformational epitope on

SUBMITTER: Smith SA 

PROVIDER: S-EPMC9831959 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature