Prognostic Impact of Coronary Flow Reserve in Patients With CKD.

ABSTRACT:

Introduction

Both coronary flow reserve (CFR) and chronic kidney disease (CKD) are known to be associated with adverse cardiac events. However, it is unclear how these prognostic factors are interrelated. This study evaluated the association between intracoronary physiologic indexes and CKD and their prognostic implications.

Methods

A total of 351 patients without left ventricular systolic dysfunction (ejection fraction ≥ 40%) and not on dialysis whose revascularization was deferred based on fractional flow reserve (FFR) > 0.80 were analyzed. Depressed CFR was defined as CFR ≤ 2.0. The primary outcome was a composite of cardiac death or hospitalization for heart failure at 3 years.

Results

Patients with CKD showed lower CFR than the non-CKD population (3.28 ± 1.77 vs.

SUBMITTER: Park S 

PROVIDER: S-EPMC9832048 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature