Patient-Specific Immersed Finite Element-Difference Model of Transcatheter Aortic Valve Replacement.

ABSTRACT: Transcatheter aortic valve replacement (TAVR) first received FDA approval for high-risk surgical patients in 2011 and has been approved for low-risk surgical patients since 2019. It is now the most common type of aortic valve replacement, and its use continues to accelerate. Computer modeling and simulation (CM&S) is a tool to aid in TAVR device design, regulatory approval, and indication in patient-specific care. This study introduces a computational fluid-structure interaction (FSI) model of TAVR with Medtronic's CoreValve Evolut R device using the immersed finite element-difference (IFED) method. We perform dynamic simulations of crimping and deployment of the Evolut R, as well as device behavior across the cardiac cycle in a patient-specific aortic root anatomy reconstructed from compu

SUBMITTER: Brown JA 

PROVIDER: S-EPMC9832092 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature