CAR-tropic extracellular vesicles carry tumor-associated antigens and modulate CAR T cell functionality.

ABSTRACT: Tumor-derived extracellular vesicles (EVs) are active contributors in metastasis and immunosuppression in tumor microenvironment. At least some of the EVs carry tumor surface molecules such as tumor-associated antigens (TAAs) and/or checkpoint inhibitors, and potentially could interact with T cells or CAR T cells. Upon contact with T cells, EVs could alter their phenotype and functions by triggering signaling through TCR or CAR reprogramming them to escape immune response. We hypothesize that EVs that possess TAA on the surface will probably interact with CAR T cells which can recognize and bind corresponding TAA. This interaction between EVs and CAR T cells may change the outcome of CAR T-based cancer immunotherapy since it should affect CAR T cells. Also, EVs could serve as adjuvants and

SUBMITTER: Ukrainskaya VM 

PROVIDER: S-EPMC9832131 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature