Variation in placental microRNA expression associates with maternal family history of cardiovascular disease.

ABSTRACT: In the United States, cardiovascular disease is the leading cause of death and the rate of maternal mortality remains among the highest of any industrialized nation. Maternal cardiometabolic health throughout gestation and postpartum is representative of placental health and physiology. Both proper placental functionality and placental microRNA expression are essential to successful pregnancy outcomes, and both are highly sensitive to genetic and environmental sources of variation. Placental pathologies, such as preeclampsia, are associated with maternal cardiovascular health but may also contribute to the developmental programming of chronic disease in offspring. However, the role of more subtle alterations to placental function and microRNA expression in this developmental programming re

SUBMITTER: Tehrani JM 

PROVIDER: S-EPMC9832176 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature