Kinetic Evaluation of the Hypoxia Radiotracers [¹⁸F]FMISO and [¹⁸F]FAZA in Dogs with Spontaneous Tumors Using Dynamic PET/CT Imaging.

ABSTRACT:

Purpose

We evaluated the kinetics of the hypoxia PET radiotracers, [18F]fluoromisonidazole ([18F]FMISO) and [18F]fluoroazomycin-arabinoside ([18F]FAZA), for tumor hypoxia detection and to assess the correlation of hypoxic kinetic parameters with static imaging measures in canine spontaneous tumors.

Methods

Sixteen dogs with spontaneous tumors underwent a 150-min dynamic PET scan using either [18F]FMISO or [18F]FAZA. The maximum tumor-to-muscle ratio (TMR_max) > 1.4 on the last image frame was used as the standard threshold to determine tumor hypoxia. The tumor time-activity curves were analyzed using irreversible and reversible two-tissue compartment models and graphical methods. TMR_max was compared with radiotracer trapping rate (k ₃),

SUBMITTER: Choen S 

PROVIDER: S-EPMC9832187 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature