Comparison of immunophenotypes between Rag2 knockout mice derived from two different sources.

ABSTRACT:

Background

Recombination activating gene2 (Rag2) knockout (KO) mice are used widely in various research fields, including vaccine development, transplantation studies, and hematopoiesis research, but few studies have compared their phenotypes. This study examined whether there were differences in the immunophenotypes between Rag2 KO mice derived from different sources. In particular, the changes in the organ weight, histological structure, and subpopulation of T and B cells were compared in the spleen and thymus of C57BL/6-Rag2^em1hwl/Korl (Rag2/Korl KO) and B6.Cg-Rag2^tm1.1Cgn/J (Rag2/J KO) mice.

Results

The weight of the spleen and thymus similarly decreased in the Rag2/Korl and Rag2/J KO mice compared to their wild type (WT) mice, even though the other

SUBMITTER: Roh YJ 

PROVIDER: S-EPMC9832259 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature