Screening and identification of potential key biomarkers for glucocorticoid-induced osteonecrosis of the femoral head.

ABSTRACT:

Background

Glucocorticoid-induced osteonecrosis of the femoral head (GIONFH) is a common disease in osteoarticular surgery, with a high disability rate, which brings great physical and mental pain and economic burden to patients. Its specific pathogenesis has not been fully demonstrated, and there is a lack of recognized effective biomarkers for earlier detection and prompt treatment. This has become an urgent clinical problem for orthopedic scholars.

Materials and methods

We downloaded the gene expression profile dataset GSE123568 from the Gene Expression Omnibus database, used STRING and Cytoscape to carry out module analysis and built a gene interaction network. The four core genes most related to GIONFH in this network were ultimately found out by precise analysis and an

SUBMITTER: Chen D 

PROVIDER: S-EPMC9832261 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature