Elucidating the Interactome of G Protein-Coupled Receptors and Receptor Activity-Modifying Proteins.

ABSTRACT: G protein-coupled receptors (GPCRs) are known to interact with several other classes of integral membrane proteins that modulate their biology and pharmacology. However, the extent of these interactions and the mechanisms of their effects are not well understood. For example, one class of GPCR-interacting proteins, receptor activity-modifying proteins (RAMPs), comprise three related and ubiquitously expressed single-transmembrane span proteins. The RAMP family was discovered more than two decades ago, and since then GPCR-RAMP interactions and their functional consequences on receptor trafficking and ligand selectivity have been documented for several secretin (class B) GPCRs, most notably the calcitonin receptor-like receptor. Recent bioinformatics and multiplexed experimental studies sugg

SUBMITTER: Kotliar IB 

PROVIDER: S-EPMC9832379 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature