Predictive markers related to local and systemic inflammation in severe COVID-19-associated ARDS: a prospective single-center analysis

ABSTRACT:

Background

As the COVID-19 pandemic strains healthcare systems worldwide, finding predictive markers of severe courses remains urgent. Most research so far was limited to selective questions hindering general assumptions for short- and long-term outcome.

Methods

In this prospective single-center biomarker study, 47 blood- and 21 bronchoalveolar lavage (BAL) samples were collected from 47 COVID-19 intensive care unit (ICU) patients upon admission. Expression of inflammatory markers toll-like receptor 3 (TLR3), heme oxygenase-1 (HO-1), interleukin (IL)-6, IL-8, leukocyte counts, procalcitonin (PCT) and carboxyhemoglobin (CO-Hb) was compared to clinical course. Clinical assessment comprised acute local organ damage, acute systemic damage, mortality and outcome after 6 months

SUBMITTER: Lieberum J 

PROVIDER: S-EPMC9832419 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature