Sleep slow waves' negative-to-positive-phase transition: a marker of cognitive and apneic status in aging.

ABSTRACT: The sleep slow-wave (SW) transition between negative and positive phases is thought to mirror synaptic strength and likely depends on brain health. This transition shows significant age-related changes but has not been investigated in pathological aging. The present study aimed at comparing the transition speed and other characteristics of SW between older adults with amnestic mild cognitive impairment (aMCI) and cognitively normal (CN) controls with and without obstructive sleep apnea (OSA). We also examined the association of SW characteristics with the longitudinal changes of episodic memory and executive functions and the degree of subjective cognitive complaints. aMCI (no/mild OSA = 17; OSA = 15) and CN (no/mild OSA = 20; OSA = 17) participants underwent a night of polysomnography and

SUBMITTER: Lafreniere A 

PROVIDER: S-EPMC9832517 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature