Tetrasodium EDTA for the prevention of urinary catheter infections and blockages† † Electronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d2ra06418a

ABSTRACT: Long-term catheterised individuals are at significant risk of developing catheter-associated urinary tract infections (CAUTIs), with up to 50% of patients experiencing recurrent episodes of catheter encrustation and blockage. Catheter blockage is a result of accumulation of carbonate apatite and struvite formed upon precipitation of ions within urine due to an infection-induced rise in pH. The aim of this study was to investigate the antimicrobial and anti-encrustation activities of tetrasodium ethylenediaminetetraacetic acid (tEDTA) to evaluate its potential efficacy in preventing CAUTIs and catheter blockages. The antimicrobial activity of tEDTA against uropathogens was assessed using time kill assays performed in artificial urine (AU). Crystallisation studies and in vitro bladder model

SUBMITTER: Moore J 

PROVIDER: S-EPMC9832581 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature