Proteomics investigation of human sera for determination of postoperative indicators of pulmonary cystic echinococcosis.

ABSTRACT:

Background

Cystic echinococcosis (CE)/hydatidosis is an important zoonotic parasitic disease caused by the larval stage of Echinococcus granulosus. The disease is a major health problem all over the world. Finding specific and sensitive biomarkers for follow-up of CE in patients after surgery is essential. Using proteomics methods, the present study aimed to evaluate post-surgical treatment by finding probable biomarker/s in the serum of human lungs CE.

Methods

A total of 24 human sera were tested. These sera included eight confirmed lung/s CE patients sera before surgery (BS), eight sera 12 months post-surgery (12MPS) as well as eight control sera from healthy people. Proteomics methods including 2DE and LC-MS/MS were performed on the specimens followed by bioinformatics an

SUBMITTER: Sadjjadi FS 

PROVIDER: S-EPMC9832791 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature