Dysfunction of the glutamatergic photoreceptor synapse in the P301S mouse model of tauopathy.

ABSTRACT: Tauopathies, including Alzheimer's disease, are characterized by retinal ganglion cell loss associated with amyloid and phosphorylated tau deposits. We investigated the functional impact of these histopathological alterations in the murine P301S model of tauopathy. Visual impairments were demonstrated by a decrease in visual acuity already detectable at 6 months, the onset of disease. Visual signals to the cortex and retina were delayed at 6 and 9 months, respectively. Surprisingly, the retinal output signal was delayed at the light onset and advanced at the light offset. This antagonistic effect, due to a dysfunction of the cone photoreceptor synapse, was associated with changes in the expression of the vesicular glutamate transporter and a microglial reaction. This dysfunction of retinal

SUBMITTER: Arouche-Delaperche L 

PROVIDER: S-EPMC9832799 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature