Glycemia Reduction in Type 2 Diabetes - Microvascular and Cardiovascular Outcomes.

ABSTRACT:

Background

Data are lacking on the comparative effectiveness of commonly used glucose-lowering medications, when added to metformin, with respect to microvascular and cardiovascular disease outcomes in persons with type 2 diabetes.

Methods

We assessed the comparative effectiveness of four commonly used glucose-lowering medications, added to metformin, in achieving and maintaining a glycated hemoglobin level of less than 7.0% in participants with type 2 diabetes. The randomly assigned therapies were insulin glargine U-100 (hereafter, glargine), glimepiride, liraglutide, and sitagliptin. Prespecified secondary outcomes with respect to microvascular and cardiovascular disease included hypertension and dyslipidemia, confirmed moderately or severely increased albuminuria or an es

SUBMITTER: GRADE Study Research Group 

PROVIDER: S-EPMC9832916 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature