Topical SCD-153, a 4-methyl itaconate prodrug, for the treatment of alopecia areata.

ABSTRACT: Alopecia areata is a chronic hair loss disorder that involves autoimmune disruption of hair follicles by CD8⁺  T cells. Most patients present with patchy hair loss on the scalp that improves spontaneously or with topical and intralesional steroids, topical minoxidil, or topical immunotherapy. However, recurrence of hair loss is common, and patients with extensive disease may require treatment with oral corticosteroids or oral Janus kinase (JAK) inhibitors, both of which may cause systemic toxicities with long-term use. Itaconate is an endogenous molecule synthesized in macrophages that exerts anti-inflammatory effects. To investigate the use of itaconate derivatives for treating alopecia areata, we designed a prodrug of 4-methyl itaconate (4-MI), termed SCD-153, with increased l

SUBMITTER: Tsai J 

PROVIDER: S-EPMC9832969 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature