DropLab: an automated magnetic digital microfluidic platform for sample-to-answer point-of-care testing-development and application to quantitative immunodiagnostics.

ABSTRACT: In point-of-care testing (POCT), tests are performed near patients and results are given rapidly for timely clinical decisions. Immunodiagnostic assays are one of the most important analyses for detecting and quantifying protein-based biomarkers. However, existing POCT immunodiagnostics mainly rely on the lateral flow assay (LFA), which has limited sensitivity or quantification capability. Although other immunodiagnostic assays, such as enzyme-linked immunosorbent assays (ELISAs), offer more sensitive and quantitative results, they require complex liquid manipulations that are difficult to implement in POCT settings by conventional means. Here, we show the development of DropLab, an automated sample-in-answer-out POCT immunodiagnostic platform based on magnetic digital microfluidic (MDM) t

SUBMITTER: Hu X 

PROVIDER: S-EPMC9833028 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature