High baseline fetuin-A levels are associated with lower atherosclerotic plaque progression as measured by 3D ultrasound.

ABSTRACT:

Background and aims

The glycoprotein fetuin-A has anti-inflammatory effects, increases insulin resistance and plays an important role in calcium metabolism. The aim of our study was to assess the predictive value of fetuin-A on atherosclerotic plaque progression in comparison to the established cardiovascular biomarker high sensitivity C-reactive protein (hsCRP).

Methods

In this prospective, single center-, cohort study, we included 194 patients with at least one cardiovascular risk factor or established cardiovascular disease (CVD). Over a period of 4 years, each patient underwent 3D plaque volumetry of the carotid and femoral arteries on a yearly basis. To evaluate the predictive value of biomarkers in terms of plaque progression, the baseline values of fetuin-A and hsCRP

SUBMITTER: Sommer P 

PROVIDER: S-EPMC9833218 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature