Identification of the atherosclerosis phenotype in vivo by vascular duplex ultrasonography in ApoE-deficient dogs.

ABSTRACT:

Background and aims

This study evaluated the atherosclerosis phenotype by vascular duplex ultrasonography (VDU) in ApoE-deficient dogs.

Methods

A total of 108 beagle dogs were examined by VDU, which included 32 wild-type, 68 heterozygous (ApoE-/+) mutant and 8 homozygous (ApoE-/-) mutant dogs. According to age, wild-type and ApoE-/+ dogs were divided into two subgroups: young (6-15 months) and adult dogs (18-29 months). All homozygous dogs were young dogs. Dogs were feed with normal diet. The plasma lipid levels were tested. The diameter of the common carotid artery (CCA), internal carotid artery (ICA), external carotid artery (ECA), abdominal aorta and common iliac artery (CIA) and the intima-media thickness (IMT) of the CCA and abdominal aorta were measured by VDU. The art

SUBMITTER: Jia L 

PROVIDER: S-EPMC9833219 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature