Burden of cardiovascular disease in a large contemporary cohort of patients with heterozygous familial hypercholesterolemia.

ABSTRACT:

Background and aims

Heterozygous familial hypercholesterolemia (HeFH) is increasingly better diagnosed and treatments can improve the cardiovascular prognosis. We evaluated the long-term cardiovascular risk of HeFH using the French REgistry of Familial hypERCHOLesterolemia (REFERCHOL).

Methods

We studied HeFH patients diagnosed genetically and clinically by the Dutch Lipid Clinic Network (DLCN) criteria in all lipid clinics across the country and their 5-year risk of cardiovascular events (all fatal and non-fatal acute coronary, cerebral and peripheral arterial disease events, aortic valve replacement surgery) using the French national health data system.

Results

The database comprised 3202 individuals, 2010 (62.8%) with genetically verified HeFH and 1192 (37.2%) a DL

SUBMITTER: Ferrieres J 

PROVIDER: S-EPMC9833221 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature