Estimated cardiovascular benefits of bempedoic acid in patients with established cardiovascular disease.

ABSTRACT:

Background and aims

Cardiovascular outcomes trials have demonstrated that lowering low-density lipoprotein cholesterol (LDL-C) reduces the risk for future cardiovascular events. We assessed the potential cardiovascular benefits of bempedoic acid through a simulation study in patients with atherosclerotic cardiovascular disease (ASCVD) and elevated LDL-C.

Methods

The validated SMART prediction model was used to estimate the baseline 10-year risk of three-point major adverse cardiovascular events (cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke) in patients with ASCVD who were enrolled in four Phase 3, randomized, placebo-controlled bempedoic acid studies. The predicted change in 10-year cardiovascular risk associated with bempedoic acid was estimat

SUBMITTER: Gunn LH 

PROVIDER: S-EPMC9833227 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature