The circulating furin-cleaved/mature PCSK9 ratio has a potential prognostic significance in statin-naive patients with acute ST elevation myocardial infarction.

ABSTRACT:

Background and aims

Proprotein convertase subtilisin/kexin type 9 (PCSK9) circulates as mature and furin-cleaved forms, but their biological functions are uncertain. We investigated whether their levels associate with prognosis in patients with acute ST elevation myocardial infarction (STEMI).

Methods

We enrolled 160 statin-naïve patients with acute STEMI and followed for 3 years. PCSK9 subtype levels were determined by an enzyme-linked immunosorbent assay before and at five timepoints up to 48 h after emergent coronary intervention. The occurrence of coronary and cardiac events was compared between subjects stratified by the PCSK9 level.

Results

One hundred and twenty-six patients completed 3 years of follow-up. In the acute phase, both PCSK9 subtype levels decreased

SUBMITTER: Sawaguchi J 

PROVIDER: S-EPMC9833232 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature