Age dependent association between remnant cholesterol and cardiovascular disease.

ABSTRACT:

Background and aims

High remnant cholesterol is associated with cardiovascular disease (CVD), but whether CVD risk attributable to remnant cholesterol vary between young and later adults remains unknown. The study aimed to assess age differences in the association between remnant cholesterol and CVD.

Methods

This prospective study included 95 663 participants without CVD and lipid-lowering treatment at baseline, including 16 254 young adults (age 18-39 years) and 79 409 later adults (age ≥40 years). Individuals were grouped by clinically meaningful remnant cholesterol concentrations of <0.50, 0.50-0.99, 1.00-1.49, and ≥1.50 mmol/L. Multivariable Cox regressions were performed to calculate hazard ratio (HR).

Results

During a median follow-up of 11.01 years, 164 inciden

SUBMITTER: Wang A 

PROVIDER: S-EPMC9833250 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature