Atherosclerosis severity in patients with familial hypercholesterolemia: The role of T and B lymphocytes.

ABSTRACT:

Background and aims

Familial hypercholesterolemia (FH) is characterized by lifelong exposure to high LDL-c concentrations and premature atherosclerotic cardiovascular disease; nevertheless, disease severity can be heterogeneous.We aimed at evaluating if the immune-inflammatory system could modulate atherosclerosis burden in FH.

Methods

From a cohort of subjects with confirmed FH (Dutch Lipid Clinic Network and genotype), 92 patients receiving high-intensity lipid-lowering therapy (statin ± ezetimibe) were included. The extension and severity of coronary atherosclerosis was assessed by standardized reporting systems (CAD-RADS) for coronary computed tomography angiography (CCTA) and coronary artery calcium (CAC) scores. Lipids, apolipoproteins, anti-oxLDL and anti-apoli

SUBMITTER: Fonzar WT 

PROVIDER: S-EPMC9833267 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature