Colchicine reduces atherosclerotic plaque vulnerability in rabbits.

ABSTRACT:

Background and aims

The anti-inflammatory agent colchicine is gaining interest as a treatment for coronary artery disease. However, the effects of colchicine in atherosclerotic animal models are mostly unknown. This study aimed to evaluate colchicine in a rabbit model of atherosclerosis.

Methods

Twenty-two rabbits were fed a 0.5% cholesterol-enriched diet for 10 weeks and then randomized to receive either oral saline (n=11) or colchicine (350 μg/kg/day; n=11) for 6 weeks, with 0.2% cholesterol-diet during the treatment period. We performed intravascular ultrasound imaging (at start and end of treatment) and histology analyses of the descending thoracic aorta. Leucocyte activation was assessed in vitro on blood samples obtained during treatment.

Results

Colchici

SUBMITTER: Roubille F 

PROVIDER: S-EPMC9833268 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature