Proteome-wide systems genetics identifies UFMylation as a regulator of skeletal muscle function.

ABSTRACT: Improving muscle function has great potential to improve the quality of life. To identify novel regulators of skeletal muscle metabolism and function, we performed a proteomic analysis of gastrocnemius muscle from 73 genetically distinct inbred mouse strains, and integrated the data with previously acquired genomics and >300 molecular/phenotypic traits via quantitative trait loci mapping and correlation network analysis. These data identified thousands of associations between protein abundance and phenotypes and can be accessed online (https://muscle.coffeeprot.com/) to identify regulators of muscle function. We used this resource to prioritize targets for a functional genomic screen in human bioengineered skeletal muscle. This identified several negative regulators of muscle function incl

SUBMITTER: Molendijk J 

PROVIDER: S-EPMC9833826 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature