Dataset Information

A novel biomarker for pleural effusion diagnosis: Interleukin-36γ in pleural fluid.

ABSTRACT:

Background

Numerous studies have described the critical importance of interleukin (IL) -36γ in host defense against lung infections, but it is unknown whether it plays a role in infectious pleural effusion (IPE). This study aimed to examine the levels of IL-36γ in pleural effusions of different etiologies and evaluate the diagnostic accuracy of IL-36γ in the differential diagnosis of IPE.

Methods

A total of 112 individuals was enrolled in this research. IL-36γ levels in pleural fluids of all 112 patients were measured by enzyme-linked immunosorbent assay (ELISA). We also characterized these markers' diagnostic values across various groups.

Results

Patients with tuberculous pleural effusion (TPE) and parapneumonic effusion (PPE) had exhibited markedly higher IL-36γ levels in their pleural fluid than the malignant pleural effusion (MPE) and transudative effusion patients. Furthermore, the IL-36γ concentrations in TPE patients were evidently higher than in uncomplicated parapneumonic effusion (UPPE) patients but significantly lower than in complicated parapneumonic effusion (CPPE)/empyema patients. Pleural fluid IL-36γ is a useful marker to differentiate TPE from UPPE, at a cut-off value for 657.5 pg/ml (area under the curve = 0.904, p < 0.0001) with 70.0% sensitivity and 95.7% specificity.

Conclusions

The elevated IL-36γ in pleural effusion may be used as a novel biomarker for infectious pleural effusion diagnosis, particularly in patients with CPPE/empyema, and is a potentially promising biomarker to differentiate between TPE and UPPE.

SUBMITTER: Guo L

PROVIDER: S-EPMC9833963 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

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Publications

A novel biomarker for pleural effusion diagnosis: Interleukin-36γ in pleural fluid.

Guo Lun L Zhang Qipan Q Lv Chengna C Ma Xudan X Song Xuxiang X Huang Jing J Chen Weili W Li Chaofen C Ding Qunli Q

Journal of clinical laboratory analysis 20221207 1

<h4>Background</h4>Numerous studies have described the critical importance of interleukin (IL) -36γ in host defense against lung infections, but it is unknown whether it plays a role in infectious pleural effusion (IPE). This study aimed to examine the levels of IL-36γ in pleural effusions of different etiologies and evaluate the diagnostic accuracy of IL-36γ in the differential diagnosis of IPE.<h4>Methods</h4>A total of 112 individuals was enrolled in this research. IL-36γ levels in pleural fl ...[more]

PMID: 36478612

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Dataset Information

A novel biomarker for pleural effusion diagnosis: Interleukin-36γ in pleural fluid.

Background

Methods

Results

Conclusions

Publications

A novel biomarker for pleural effusion diagnosis: Interleukin-36γ in pleural fluid.

Similar Datasets

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