Serum calprotectin can indicate current and future severity of COVID-19.

ABSTRACT:

Background

Predictive and prognostic biomarkers to guide 2019 novel coronavirus disease (COVID-19) are critically evolving. Dysregulated immune responses are the pivotal cause of severity mainly mediated by neutrophil activation. Thus, we evaluated the association of calprotectin, neutrophil secretory protein, and other mediators of inflammation with the severity and outcomes of COVID-19.

Methods

This two-center prospective study focused on PCR-proven COVID-19 patients (n = 76) with different clinical presentations and SARS-CoV-2 negative control subjects (n = 24). Serum calprotectin (SC) was compared with IL-6 and other laboratory parameters.

Results

Median levels of SC were significantly higher in COVID-19 patients in comparison to the control group (3760 vs. 2100 n

SUBMITTER: Shokri-Afra H 

PROVIDER: S-EPMC9833977 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature