Polysaccharides from Panax ginseng promote intestinal epithelial cell migration through affecting the Ca²⁺ related regulators.

ABSTRACT:

Background and aim

Panax ginseng, a key herbal medicine of replenishing Qi and tonifying Spleen, is widely used in the treatment of gastrointestinal diseases in East Asia. In this study, we aim to investigate the potential effects and mechanisms of polysaccharides from P. ginseng (PGP) on intestinal mucosal restitution which is one of the crucial repair modalities during the recovery of mucosal injury controlled by the Ca²⁺ signaling.

Methods

Rat model of intestinal mucosal injury was induced by indomethacin. The fractional cell migration was carried out by immunohistochemistry staining with BrdU. The morphological observations on intestinal mucosal injury were also performed. Intestinal epithelial cell (IEC-6) migration in vitro was conducted by scr

SUBMITTER: Zhu H 

PROVIDER: S-EPMC9834020 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature