Ginseng-derived nanoparticles induce skin cell proliferation and promote wound healing.

ABSTRACT:

Background

Past studies suggested that ginseng extracts and ginseng-derived molecules exerted significant regulatory effects on skin. However, no reports have described the effects of ginseng-derived nanoparticles (GDNPs) on skin cell proliferation and wound healing. In this study, we investigated whether GDNPs regulate the proliferation of skin cells and promote wound healing in a mouse model.

Methods

GDNPs were separated and purified via differential centrifugation and sucrose/D2O gradient ultracentrifugation. GDNP uptake, cell proliferation and cell cycle progression were measured by confocal microscopy, CCK-8 assay and flow cytometry, respectively. Cell migration and angiogenic effects were assessed by the wound scratch assay and tube formation assay, respectively. ELISA

SUBMITTER: Yang S 

PROVIDER: S-EPMC9834025 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature