Association of demographic and clinical factors with risk of acute pancreatitis: An exposure-wide Mendelian randomization study.

ABSTRACT: The incidence of acute pancreatitis (AP) is increasing over years, which brings enormous economy and health burden. However, the aetiologies of AP and underlying mechanisms are still unclear. Here, we performed a two-sample Mendelian randomization (MR) analysis to investigate the associations between all reported possible risk factors and AP using publicly available genome-wide association study summary statistics. A series of quality control steps were taken in our analysis to select eligible instrumental single nucleotide polymorphisms which were strongly associated with exposures. To make the conclusions more robust and reliable, we utilized several analytical methods (inverse-variance weighting, MR-PRESSO method, weighted median, MR-Egger regression) that are based on different assumpt

SUBMITTER: Tang QY 

PROVIDER: S-EPMC9834139 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature