Annexin A1 affects tumor metastasis through epithelial-mesenchymal transition: a narrative review.

ABSTRACT:

Background and objective

Annexin A1 (annexin I, ANXA1), the first discovered member of the annexin superfamily, plays important roles in tumor development, invasion, metastasis, apoptosis and drug resistance based on tumor type-specific patterns of expression. The acquisition of the epithelial-mesenchymal transition (EMT) characteristics is an essential mechanism of metastasis because they increase the mobility and invasiveness of cancer cells. Cancer invasion and metastasis remain major health problems worldwide. Elucidating the role and mechanism of ANXA1 in the occurrence of EMT will help advance the development of novel therapeutic strategies. Hence, this review aims to attract everyone's attention to the important role of ANXA1 in tumors and provide new ideas for clinical tumo

SUBMITTER: Zheng L 

PROVIDER: S-EPMC9834584 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature